| dc.description.abstract | Little information is available on the e ect of COVID-19 infection on biochemistry of
Sri Lankan patients. Owing to this lack of information, prognosis on development
of complications were di cult to predict. Hence, this study aimed to investigate the
variations of biochemical parameters of infected patients admitted at Colombo South
Teaching Hospital from January 2020 to December 2021. This retrospective crosssectional
descriptive study used records of 203 COVID-19 patients, who had been treated
for an average of 9 days. Information on age, length of stay, gender, symptoms, previous
medical history, results of selected biochemical parameters and pharmacological interventions
were collected from medical records. Laboratory tests records were collected
which had been done with standard methods and quality controlled by EQA by MRI.
The data was analyzed using the SPSS software (student t-test and Pearson correlations).
Decreased serum sodium was reported in 150 patients on admission and average urea
levels were signi cantly elevated (p < 0.05) from admission to discharge. Decline in eGFR
levels (69.5-93.9 mL/min/1.73m2) were observed in 34 out of 51 patients 5 to 7 days after
admission. Elevated serum ferritin was observed in 31 out of 35 on admission and elevated
ALT values were observed in 51 out of 90 patients on discharge. High AST levels were
reported on admission in 71 out of 164 patients. Comparing results with other countries it
has been reported decreased sodium levels elevated serum urea, AST, ALT and GGT and
serum creatinine levels in patients. Owing to the results, it was concluded that COVID-19
could induce liver and kidney involvements. | en_US |
