Intracoronary Transplantation of Autologous Haematopoietic Stem Cells in Ischaemic Endstage Left Ventricular Failure

Abstract

The prevalence of end-stage heart failure is rising despite presence of successful reperfusion strategies for treating acute myocardial infarction and advancements made in pharmacological and device therapy optimized for heart failure management. The non-availability of a mature cardiac transplantation programme and absence of left and right ventricular assist devices in many parts of the world has renewed interests in potential alternative options. We demonstrate the preliminary observational data (not a trial) of a beneficial effect of intra coronary autologous bone marrow derived peripheral haemopoietic stem cell transplantation to improve myocardial contractility. Systematic and cellular level analysis on these cells will be required to optimize therapeutic utility of this emerging regenerative medical speciality.