| dc.description.abstract | White matter and grey matter changes in epilepsy detected by Voxel-based
morphometry (VBM) and Tensor-based morphometry (TBM) shows notable
similarities and differences to date. Therefore, a direct comparison of results using
VBM and TBM is necessary to understand how different methods are sensitive in
detecting structural brain changes in epilepsy. 45 patients with epilepsy and 46
healthy controls were scanned using a 3 Tesla MRI scanner. Sagittal, 3D, T1
weighted brain images were acquired from each subject. The data were analysed
using Computational Anatomy Toolbox – CAT12. For VBM, voxel-wise grey matter
volumes (VBM-GM), white matter volumes (VBM-WM) and Cerebrospinal fluid
volumes (CSF-GM) were computed and smoothed (FWHM= 8 mm) for each
participant. For TBM, voxel-wise Jacobian determinants were obtained and
smoothed (FWHM= 8 mm). Finally, the group differences between patients and
controls were detected using two-sample T-tests and results were interpreted
without corrections for multiple comparison errors (p< 0.001, uncorrected).
Univariate analysis showed widely spread morphological changes covering all lobes
in the brains of epileptic patients. Volume reductions of GM were reported in the
cerebellum, middle temporal gyrus, left occipital, right hippocampal, right para
hippocampal, left superior frontal and left insula. WM volume reductions were
mostly highlighted in the cerebellum. In addition, gross tissue volume reductions
were detected in the cerebellum, middle occipital, middle temporal, left superior
frontal, right inferior frontal, extra nuclear and frontal sub-gyral regions.
Conjunction analysis of above results showed that although both methods detected
widespread structural changes, there are similarities and differences in GM and WM
findings. Therefore, we conclude that VBM and TBM are differently sensitive in
detecting structural brain changes in epilepsy. | en_US |
