| dc.description.abstract | Metformin, being noteworthy, is used in
the management of Type 2 Diabetes. It is available in
different brands in Sri Lanka. Several studies have
shown that different brands of the drug varied
qualities, which could impact the treatment efficacy.
This study was conducted to analyse the quantity of
different brands of metformin hydrochloride tablets
available in the Jaffna municipal area, Sri Lanka. It
was a laboratory-based exploratory study conducted
in State Pharmaceutical Manufacturing Corporation,
Sri Lanka. Based on most available brands at
pharmacies in the Jaffna Municipal area, fifteen
brands of conventional metformin tablets were
selected for this study. They were coded as M1, M2,
M3,… M15. The uniformity of weight, hardness,
friability, disintegration, uniformity of content, and
dissolution tests were performed in accordance with
the British Pharmacopeia (BP). Two out of fifteen
brands were locally manufactured, and the
remaining were imported. All brands were
conformed to BP specifications in uniformity of
weight. The hardness test showed optimum
withstanding strength in all brands. All brands
excluding M1 (108.95%), M6 (111.58%), M7 (94.27%)
and M11 (93.91%) were comprised of values falling
under monograph specifications (95% -105%) for
uniformity of content. Twelve brands satisfied
Pharmacopeia requirements in the friability test,
while two brands, M7 (40.45 min) and M10 (34.5
minutes), failed in the disintegration test. The
dissolution of one brand showed the least drug
release (61.40%), and the remaining passed the
dissolution test. In conclusion, of all the metformin
hydrochloride brands, nine brands passed all the
official tests according to BP specifications. | en_US |
