Development of Neem Oil and Virgin Coconut Oil Based Cream Formulations with Methanolic Extract of Leucas zeylanica and Ophiorrhiza mungos leaves
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Date
2020Author
Pillay, F.A.S.S
Ranasinghe, R.A.H.M
Perera, W.K.S.P
Sanjeewani, N. A.
Siriwardhene, M. A.
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Abstract: Ultraviolet radiations (UV) cause numerous
skin diseases when exposed in excess.
Ophiorrhiza mungos (OM) and Leucas
zeylanica (LZ) have identified as plants with
high Sun Protection Factor (SPF) values.
Neem oil and Virgin Coconut Oil (VCO) are
natural oils that have been used in Ayurvedic
medicine for several indications. The
objective of the study was to evaluate the SPF
activity and carry out stability studies in
Neem oil and VCO based cream formulations
consisted with methanolic extracts of OM
and LZ. The Methanolic extracts were
incorporated in to selected ratios of VCO and
Neem oil bases. Samples were subjected to
secondary homogenization. Most stable
ratios of the emulsions were identified as
33% VCO: 35% water: 32% T80, and 29%
Neem oil: 42% water: 29% T80. Cream
formulations were prepared based on above
identified ratios. All creams were
thermodynamically and kinetically stable
more than 120 days at room temperature
(28± 2 0C). The SPF values of creams were
above 30 and they showed higher SPF values
compared to the pure leaf extracts of OM and
LZ. Neem oil based creams had the highest
SPF values which is greater than 38. The
creams were o/w type and in the acceptable
pH range for topical application. Due to the
consistency of the creams, they could retain
on the skin for longer period. All creams
composed with other standard sunscreen
characteristics which increase the market
value of the product.