Antimicrobial Susceptibility Patterns Of Blood Culture Isolates From Cancer Patients After Anti-Cancer Therapy.
Date
2020Author
Flemin, RM
Thakshala, SAR
Gunasekara, SP
Chandana, AK
Senaratne, UTN
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Abstract: Blood stream infections (BSI) have
a major impact on cancer patients.
Antimicrobial patterns in pathogens should
be analyzed by routine surveillance since
they vary among different healthcare
facilities and geographical area. This study
focuses on epidemiology, clinical features,
and antimicrobial profiles of cancer patients
with BSI after anticancer therapy. A
Descriptive cross-sectional study was
conducted within a period of 4 months. The
causative agents and antibiotic profiles were
studied according to Clinical Laboratory
Standards institutes (CLSI) and VITEK
automated system. Antibiotic profiles of
organisms and antibiotic resistance patterns
were analyzed in terms of frequency. The
prevalence of BSI was 11.75%. Gram
negative bacilli (GNB) were higher than gram
positive cocci (GPC). Among GNB the most
prevalent was Klebsiella pneumoniae and
among GPC it was, Staphylococcus aureus.
Prevalence of multi-drug resistance (MDR)
was 78.8%. High resistance to Erythromycin
was seen in patients with hematological
cancers while high resistance to Benzyl
penicillin was seen in patients with solid
cancers. Chemotherapy had no significant
impact on presence of multi-drug resistance
while the association between CRP with ANC
and presence of fever was not significant.
Among different antibiotic resistant groups,
ESBL and Carbapenem resistances were
noted. According to our study high
prevalence of antimicrobial resistance in
Gram-negative isolates and emergence of
MDR pathogens is alarming. Investigation of
novel antibiotics, usage of combination
therapy and usage according to the standard
antimicrobial susceptibility testing may help
to decrease or prevent the emergence of
antibiotic resistance.