| dc.description.abstract | Aponogeton crispus and Aponogeton rigidifolius
are native Aponogeton plants in Sri Lanka. These
are widely used in folkloric medicine. Recent
pharmacological studies have established antidiabetic,
anti-inflammatory, anti-oxidant, anticancer
and thrombolytic activities of Aponogeton
species. Aim of this study was to evaluate the
effect of A. crispus and A. rigidifolius on acute
inflammatory response. A. crispus and A.
rigidifolius flowers and their stalks were collected
and the extract was prepared by standard
ayurvedic method. Carrageenan (1%, 0.1 ml)
induced paw oedema in Wistar rats model was
used to evaluate the acute anti- inflammatory
activity. One hour before the carrageenan
injection, positive control 15 mg/kg dichlofenac
sodium, negative control – distilled water and
test samples (A. crispus- 90 mg/kg; A. rigidifolius-
90 mg/kg) were administered orally. Digital
plethysmometer was used to measure the anti-inflammatory
effects at every hour interval
for 5 hours to see the paw oedema percentage
inhibition and the effect was also compared
with extract, control and standard. Carrageenan
injection into the left hind paw induced oedema
progressively and maximum oedema reached
at 3rd hour. Dichlofenac sodium, A. rigidifolius
showed the maximum inhibition of 61.3% and
62% respectively at the 3rd hour. Aponogeton
crispus showed the maximum inhibition of 65.9%
at the 4th hour and 60% at the 3rd hour. Aqueous
extract of two plant species of Aponogeton showed
a significant percentage inhibition of oedema in
the hind paw and anti-inflammatory activities
compared to control demonstrate that it will
be useful for the management of acute anti-inflammatory
disorders. | en_US |
