| dc.description.abstract | Globally there is a massive increase in the
prevalence of Multi Drug Resistant (MDR) strains
of Acinetobacter baumannii and Pseudomonas
aeruginosa. Hence it is considered one of the
biggest threats in the health care sector in the 21st
century. Nosocomial infections known as hospital
acquired infections (HAI) are associated with a
great deal of morbidity, mortality and increased
financial burden. The misappropriations of
antimicrobial agents create the emergence of
prominent MDR strains. This study has been
evaluated to fulfill the gaps by the antimicrobial
effects against Acinetobacter baumannii (ATCC®
19606 ™) and Pseudomonas aeruginosa (ATCC®
27853 ™) using the aqueous extracts of flowers,
seeds, leaves, bark and root of Lawsoniainermis
L. plant. The antibacterial activity of the extracts
was evaluated using the cylinder plate method,
and Gentamycin was used as the positive control
while distilled water used as negative control.
A series of concentrations was made with all six
plant parts (flowers, seeds, leaves, bark, rootand
combination). The concentrations used were 250
μg/ml, 500 μg/ml, 750 μg/ml and 1000 μg/ml.
Results revealed that all aqueous extractions
exhibit marked antibacterial activity zones of
inhibition values ranging between 12.94 mm
to 19.72 mm and 12.87 mm to 19.66 mm against
A.baumannii and P.aeruginosa respectively. The
result is statistically significant (p< 0.05). It is
concluded that Aqueous extraction of the flower
of Lawsoniainermis L. plant showed the highest
antibacterial activity while aqueous extraction
of combination showed the second highest
antibacterial activity against both Acinetobacter
baumannii (ATCC 19606) and Pseudomonas
aeruginosa (ATCC 27853) respectively. This is
a discovery of novel antibiotic for nosocomial
infections in future. | en_US |
