| dc.description.abstract | Hematological parameters of patients with
chronic kidney disease (CKD) in Girandurukotte
and Mahiyanganaya areas were followed in
a cross-sectional study that comprised 175
volunteer subjects. Whole blood, urine and
background information were collected from
each under informed consent. The study spanned
all five stages of CKD progression and a control
(estimated glomerular filtration rate, eGFR>120
ml/min/1.73m2). Erythrocyte, leukocyte (total
and differential) and platelet counts, hemoglobin
and hematocrit levels were obtained from an
automated hematology analyzer. In addition,
total and differential leukocyte counts were
made from Giemsa stained blood smears. Disease
progression was followed in terms of kidney
dysfunction markers; serum creatinine based
eGFR (MDRD equation) and urine albumin to
creatinine ratio (UACR, mg/g). Results showed
inter stage differences in hemoglobin levels,
erythrocyte, lymphocyte, monocyte and basophil
numbers of automated counts, and in lymphocytes
and monocytes in blood smears (p>0.001, oneway
ANOVA with Tukey HSD). Pearson’s linear
correlation of hematology parameters with disease
progression revealed significant associations
(p<0.001) of eGFR with the automated counts
of erythrocytes (r<0.001), hemoglobin (r<0.001),
hematocrit (r=0.001), total leukocytes (r=0.002),
lymphocytes (r<0.001), monocytes (r<0.001), and
basophils (r=-0.012). Platelets showed a positive
correlation (r=0.015, p<0.05). UACR significantly
(p<0.001) associated with erythrocytes (r=-0.006),
hemoglobin (r=-0.005), hematocrit (r=-0.009),
lymphocytes (r<0.001), monocytes (r=-0.004) and
basophils (r=0.008). Counts from blood smears
showed correlation (p<0.001) of eGFR to total
leukocytes (r=0.005), lymphocytes (r<0.001) and
monocytes (r<0.001) while UACR associated with
lymphocytes (r<-0.001) and monocytes (r=-0.001).
Results collectively revealed that the blood cell
counts change with CKD disease progression. | en_US |
