| dc.description.abstract | Chronic Myeloid Leukemia (CML) is a
hematological malignancy. Some studies
have reported structural abnormalities in the
erythrocyte membrane in CML which may
contribute to its anemia. This study was performed
to determine the erythrocyte membrane fragility
of CML patients associated with anemia using
Osmotic Fragility (OF) test. An experimental
study was carried out between 20 voluntary
Philadelphia chromosome positive anemic CML
patients and 25 voluntary healthy controls. OF
test was performed; median corpuscular fragility
(MCF) and initial lysis were obtained. The data
were analyzed by SPSS software version 20.0. The
MCF of controls were within the reference range
(Mean 4.23, SD 0.11) and for the patient group, the
MCF values were ranged in 3.67-4.60 g/l (Mean
4.22, SD 0.38). The initial lysis values of the control
group were within the range of 5.0-6.0 g/l with
mean value of 5.36 g/l (SD 0.42) and the patients’
initial lysis values were within 6.00-8.00 g/l with
mean value of 7.07 g/l (SD0.69), representing a
significant difference between the control and
the patient group (Non parametric test; P=0.000<
0.05). However, the MCF of the control and the
patient group did not provide a significant
difference. Initial lysis plays an important role
in the OF test as it could detect hemolysis in
advance. The significant increase in initial lysis
values in the patients group compared to controls
may have been resulted from a sub population of
erythrocytes with defected membranes. | en_US |
